SP1-mediated long noncoding RNA POU3F3 accelerates the cervical cancer through miR-127-5p/FOXD1.
作者： Suwen Chang , Liping Sun , Guijiao Feng
DOI: 10.1016/J.BIOPHA.2019.109133
关键词:
摘要: Abstract Emerging evidence supports the critical roles of long noncoding RNA (lncRNA) in cervical cancer. However, pathological lncRNA POU3 F3 cancer tumorigenesis are still elusive. was validated to be up-regulated tissue specimens and cells comparing with normal controls. Moreover, ectopic overexpression closely correlated poor prognosis. In vitro, promoted proliferation, invasion cells. vivo, knockdown repressed tumor growth The transcriptional expression activated by transcription factor SP1. Mechanically, acted as sponge target miR-127-5p, while miR-127-5p bind 3′-UTR FOXD1 gene. conclusion, our data verifies that POU3 F3, induced SP1, acts an oncogene via regulating miR-127-5p/FOXD1 axis, providing a possible therapeutic for
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