Functional linc-POU3F3 is overexpressed and contributes to tumorigenesis in glioma.
作者： Hua Guo , Lei Wu , Qing Yang , Minhua Ye , Xingen Zhu
DOI: 10.1016/J.GENE.2014.10.038
关键词:
摘要: Growing number of long intergenic noncoding RNAs (lincRNAs) have recently been identified in mammals as new modulators cancer origination and progression involved a broad range biological processes. Long RNA POU3F3 (linc-POU3F3) has characterized highly conserved functional transcription regulator esophageal squamous cell carcinoma. The contributions this lincRNA to glioblastoma remain unknown. In present study, we investigated the expression pattern role linc-POU3F3 glioma by using real-time PCR gain-/loss-of-function studies. results revealed that levels were extraordinarily associated with tumor WHO grade. related biochemical assays, overexpression promotes viability proliferation cells, whereas knockdown showed opposite effect. As expected, also found was negatively correlated mRNA level (the evolutionarily neighbor gene linc-POU3F3). Our indicate might affect development via altering POU3F3, lead us believe may crucial regulatory progression.
elsevier.com
sci-hub.se 参考文章(41)
FB Rahmatpanah, S Carstens, J Guo, O Sjahputera, KH Taylor, D Duff, H Shi, JW Davis, SI Hooshmand, R Chitma-Matsiga, CW Caldwell, None, Differential DNA methylation patterns of small B-cell lymphoma subclasses with different clinical behavior Leukemia. ,vol. 20, pp. 1855- 1862 ,(2006) , 10.1038/SJ.LEU.2404345
Andrea Pauli, John L. Rinn, Alexander F. Schier, Non-coding RNAs as regulators of embryogenesis Nature Reviews Genetics. ,vol. 12, pp. 136- 149 ,(2011) , 10.1038/NRG2904
Kevin C. Wang, Yul W. Yang, Bo Liu, Amartya Sanyal, Ryan Corces-Zimmerman, Yong Chen, Bryan R. Lajoie, Angeline Protacio, Ryan A. Flynn, Rajnish A. Gupta, Joanna Wysocka, Ming Lei, Job Dekker, Jill A. Helms, Howard Y. Chang, A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression Nature. ,vol. 472, pp. 120- 124 ,(2011) , 10.1038/NATURE09819
Emmanuelle Viré, Carmen Brenner, Rachel Deplus, Loïc Blanchon, Mario Fraga, Céline Didelot, Lluis Morey, Aleyde Van Eynde, David Bernard, Jean-Marie Vanderwinden, Mathieu Bollen, Manel Esteller, Luciano Di Croce, Yvan De Launoit, François Fuks, None, The Polycomb group protein EZH2 directly controls DNA methylation Nature. ,vol. 439, pp. 871- 874 ,(2006) , 10.1038/NATURE04431
Vidisha Tripathi, Jonathan D. Ellis, Zhen Shen, David Y. Song, Qun Pan, Andrew T. Watt, Susan M. Freier, C. Frank Bennett, Alok Sharma, Paula A. Bubulya, Benjamin J. Blencowe, Supriya G. Prasanth, Kannanganattu V. Prasanth, The nuclear-retained noncoding RNA MALAT1 regulates alternative splicing by modulating SR splicing factor phosphorylation. Molecular Cell. ,vol. 39, pp. 925- 938 ,(2010) , 10.1016/J.MOLCEL.2010.08.011
Michael Wegner, C. Claus Stolt, From stem cells to neurons and glia: a Soxist's view of neural development. Trends in Neurosciences. ,vol. 28, pp. 583- 588 ,(2005) , 10.1016/J.TINS.2005.08.008
Dandan Li, Jiapeng Feng, Tianyi Wu, Yandong Wang, Yanan Sun, Jingyuan Ren, Ming Liu, Long Intergenic Noncoding RNA HOTAIR Is Overexpressed and Regulates PTEN Methylation in Laryngeal Squamous Cell Carcinoma The American Journal of Pathology. ,vol. 182, pp. 64- 70 ,(2013) , 10.1016/J.AJPATH.2012.08.042
Irfan A. Qureshi, John S. Mattick, Mark F. Mehler, Long non-coding RNAs in nervous system function and disease. Brain Research. ,vol. 1338, pp. 20- 35 ,(2010) , 10.1016/J.BRAINRES.2010.03.110
Raymond K Mulhern, Thomas E Merchant, Amar Gajjar, Wilburn E Reddick, Larry E Kun, Late neurocognitive sequelae in survivors of brain tumours in childhood. Lancet Oncology. ,vol. 5, pp. 399- 408 ,(2004) , 10.1016/S1470-2045(04)01507-4
Kevin C. Wang, Howard Y. Chang, Molecular Mechanisms of Long Noncoding RNAs Molecular Cell. ,vol. 43, pp. 904- 914 ,(2011) , 10.1016/J.MOLCEL.2011.08.018