RhoB as a suppressor of cancer cell growth, cell transformation, and metastasis
作者： Said M. Sebti
DOI:
关键词:
摘要: The present invention concerns the use of protein RhoB and its variants to inhibit cancer cell growth, migration, invasion, metastasis, malignant transformation, and/or modulate oncogenic signaling, wherein introducing directly, or indirectly via a nucleic acid sequence encoding RhoB, into malignantly transformed cancerous decreases phosphorylation Erk Akt proteins inhibiting PI3-kinase/Akt survival pathway promoting apoptotic death. In one aspect, compositions methods are used transformation cells by oncogenes H-Ras, N-Ras, K-Ras, EGFR, ErbB2, growth such oncogenes. may be signaling in vivo vitro.
lens.org参考文章(71)
Christoph W. M. Reuter, Michael A. Morgan, Lothar Bergmann, Targeting the Ras signaling pathway: a rational, mechanism-based treatment for hematologic malignancies? Blood. ,vol. 96, pp. 1655- 1669 ,(2000) , 10.1182/BLOOD.V96.5.1655
Alexis L. Stewart, Abner M. Mhashilkar, Xiaohong Helena Yang, Suhendan Ekmekcioglu, Yuji Saito, Kerry Sieger, Robert Schrock, Eric Onishi, Xin Swanson, John B. Mumm, Lou Zumstein, Graham J. Watson, David Snary, Jack A. Roth, Elizabeth A. Grimm, Rajagopal Ramesh, Sunil Chada, PI3K Blockade by Ad-PTEN Inhibits Invasion and Induces Apoptosis in Radial Growth Phase and Metastatic Melanoma Cells Molecular Medicine. ,vol. 8, pp. 451- 461 ,(2002) , 10.1007/BF03402025
Marie-Annick Forget, Richard R. Desrosiers, Rolanda F. Del Maestro, Robert Moumdjian, Daniel Shedid, France Berthelet, Richard Béliveau, The expression of rho proteins decreases with human brain tumor progression: potential tumor markers. Clinical & Experimental Metastasis. ,vol. 19, pp. 9- 15 ,(2002) , 10.1023/A:1013884426692
P Adamson, C.J. Marshall, A Hall, P.A. Tilbrook, Post-translational modifications of p21rho proteins. Journal of Biological Chemistry. ,vol. 267, pp. 20033- 20038 ,(1992) , 10.1016/S0021-9258(19)88661-1
C.J. Vlahos, W.F. Matter, K.Y. Hui, R.F. Brown, A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). Journal of Biological Chemistry. ,vol. 269, pp. 5241- 5248 ,(1994) , 10.1016/S0021-9258(17)37680-9
Caroline J. Fuery, Tanya L. Applegate, Walter Wouters, Gerard Sanz, Marc Venet, Ann Devine, Stacy Skrzat, Gerda Smets, David W. End, Charles Bowden, Patrick Angibaud, Alison V. Todd, Herve Poignet, Characterization of the Antitumor Effects of the Selective Farnesyl Protein Transferase Inhibitor R115777 in Vivo and in Vitro Cancer Research. ,vol. 61, pp. 131- 137 ,(2001)
Said M. Sebti, Rhob as a suppressor of cancer cell growth and cell transformation ,(2001)
Inder M Verma, Nikunj Somia, None, Gene therapy -- promises, problems and prospects Nature. ,vol. 389, pp. 239- 242 ,(1997) , 10.1038/38410
George C. Prendergast, Wei Du, Geranylgeranylated RhoB Mediates Suppression of Human Tumor Cell Growth by Farnesyltransferase Inhibitors Cancer Research. ,vol. 59, pp. 5492- 5496 ,(1999)
Jalila Adnane, Edward Seijo, Zhi Chen, Francisco Bizouarn, Martha Leal, Said M. Sebti, Teresita Muñoz-Antonia, RhoB, Not RhoA, Represses the Transcription of the Transforming Growth Factor β Type II Receptor by a Mechanism Involving Activator Protein 1 Journal of Biological Chemistry. ,vol. 277, pp. 8500- 8507 ,(2002) , 10.1074/JBC.M104367200