Rhob as a suppressor of cancer cell growth and cell transformation
作者： Said M. Sebti
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摘要: The protein RhoB and its variants as a supressor of cancer cell growth, inhibitor malignant transformation, modulator oncogenic signaling, wherein introducing directly, or indirectly via nucleic acid, into malignantly transformed cancerous decreases phosphorylation Erk Akt proteins inhibiting the PI3-kinase/Akt survival pathway promoting apoptotic death. Methods compositions are disclosed for administering to patients, prophylactic treatment minimize risk advantageous combination therapy with existing treatments. present invention prenylated either geranylgeranyl farnesyl, provision is made selection prenylating moiety.
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