Role ofHelicobacter pyloriin gastric mucosa-associated lymphoid tissue lymphomas

摘要: Mucosa-associated lymphoid tissue (MALT) lymphoma is an indolent extranodal marginal zone B-cell lymphoma, originating in acquired MALT that induced mucosal barriers as part of a normal adaptive immune response to chronic immunoinflammatory stimulus, most notably infection by Helicobacter pylori (H. pylori). This antigenic stimulation initially leads hyperplasia; the acquisition additional genetic aberrations culminates activation intracellular survival pathways, with disease progression due proliferation and resistance apoptosis, emergence malignant clone. There are descriptions lymphomas affecting practically every organ system, marked geographic variability partially attributable epidemiology underlying risk factors; nevertheless, digestive system (and predominantly stomach) frequently involved location, reflecting gastrointestinal tract's unique characteristics contact foreign antigens, high permeability, large extension intrinsic system. While early-stage gastric can regress after therapeutic reversal stimulus through antibiotic eradication H. infection, presence immortalizing abnormalities, advanced or eradication-refractoriness requires more aggressive approach which is, presently, not consensual. The fact rare neoplasms, worldwide incidence 1-1.5 cases per 10⁵ population, year, limits ease accrual representative series patients for robust clinical trials could sustain informed evidence-based decisions optimize quality patient care.