Molecular Aspects of H. pylori-Related MALT Lymphoma

摘要: Helicobacter pylori-related extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue is a paradigm for malignancy arising in an inflammatory background. While the diagnosis H. pylori gastritis often straightforward, distinction between severe and early can be difficult requires careful assessment clinical findings addition to histological features immunohistochemical results. A number cytogenetic abnormalities have been discovered lymphomas several importance, related responsiveness eradication therapy, but routine molecular studies are not widely utilized. methods may used equivocal cases, trial conservative therapy warranted given propensity these regress with organism. Once initiated, care must taken avoid premature assignment disease refractoriness because complete response take months more than year. Cases truly refractory treated adjuvant chemoradiation high rate.