Insights on the Structural Characteristics of NDM-1: The Journey so Far
作者： Avneet Saini , Rohit Bansal , None
关键词:
摘要: New Delhi metallo-β-lactamase (NDM-1) has created a medical storm ever since it was first reported; as is active on virtually all clinically used β-lactam antibiotics. NDM-1 rampancy worldwide now considered nightmare scenario, particularly due to its rapid dissemination. An underlying theme in the majority of recent studies structural characterization knowledge three-dimensional structure shall help find connections between and function. Moreover, details are even critical order reveal resistance mechanism In this perspective, we review characteristics that have been delineated report. We anticipate these structure-function made by further serve future guidelines for elucidating pathways towards de novo design functional inhibitors.
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