Nasopharyngeal Carcinoma: Genetics and Genomics
作者： Maria Li Lung , Wei Dai , Josephine Mun-Yee Ko
DOI: 10.1016/B978-0-12-814936-2.00002-X
关键词:
摘要: Abstract This chapter introduces the genetics and genomics of nasopharyngeal carcinoma (NPC). We introduce, in brief, findings leading to current state knowledge what we know about molecular genetic basis NPC prior new advances next-generation sequencing, which have allowed a more global view impact variations, epigenetic regulation, cell signaling pathways that contribute development. Discussions on germline predisposition for include MST1R, HLA, telomere, DNA repair studies, subjects appear play important roles inherited NPC. Landscape methylome, genome, transcriptome sequencing studies identified genes aberrations, providing insights into These all indicate complex multifactorial nature
hku.hk
sci-hub.se 参考文章(185)
Wing Lung Yau, Hong Lok Lung, Eugene R. Zabarovsky, Michael I. Lerman, Jonathan Shun-tong Sham, Daniel Tsin-tien Chua, Sai Wah Tsao, Eric J. Stanbridge, Maria Li Lung, Functional studies of the chromosome 3p21.3 candidate tumor suppressor gene BLU/ZMYND10 in nasopharyngeal carcinoma. International Journal of Cancer. ,vol. 119, pp. 2821- 2826 ,(2006) , 10.1002/IJC.22232
Alissa Michelle Go Wong, Kar Lok Kong, Leilei Chen, Ming Liu, Aikha Melissa Go Wong, Cailei Zhu, Janice Wing-hang Tsang, Xin-Yuan Guan, Characterization of CACNA2D3 as a putative tumor suppressor gene in the development and progression of nasopharyngeal carcinoma. International Journal of Cancer. ,vol. 133, pp. 2284- 2295 ,(2013) , 10.1002/IJC.28252
Juan Chen, Dora Lai-Wan Kwong, Cai-Lei Zhu, Lei-Lei Chen, Sui-Sui Dong, Li-Yi Zhang, Jun Tian, Chu-Bo Qi, Ting-Ting Cao, Alissa Michelle Go Wong, Kar-Lok Kong, Yan Li, Ming Liu, Li Fu, Xin-Yuan Guan, RBMS3 at 3p24 Inhibits Nasopharyngeal Carcinoma Development via Inhibiting Cell Proliferation, Angiogenesis, and Inducing Apoptosis PLoS ONE. ,vol. 7, pp. e44636- ,(2012) , 10.1371/JOURNAL.PONE.0044636
Xing-sheng Shu, Lili Li, Mingfang Ji, Yingduan Cheng, Jianming Ying, Yichao Fan, Lan Zhong, Xiaodong Liu, Sai Wah Tsao, Anthony TC. Chan, Qian Tao, FEZF2, a novel 3p14 tumor suppressor gene, represses oncogene EZH2 and MDM2 expression and is frequently methylated in nasopharyngeal carcinoma Carcinogenesis. ,vol. 34, pp. 1984- 1993 ,(2013) , 10.1093/CARCIN/BGT165
Joseph Kwong, Lillian Shuk‐Nga Chow, Albert Yue‐Hang Wong, Wing‐Ki Hung, Grace Tin‐Yun Chung, Ka‐Fai To, Franky L Chan, Yataro Daigo, Yusuke Nakamura, Dolly P Huang, Kwok‐Wai Lo, None, Epigenetic inactivation of the deleted in lung and esophageal cancer 1 gene in nasopharyngeal carcinoma. Genes, Chromosomes and Cancer. ,vol. 46, pp. 171- 180 ,(2007) , 10.1002/GCC.20398
Joseph Kwong, Kwok‐Wai Lo, Lillian Shuk‐Nga Chow, Franky Leung Chan, Ka‐Fai To, Dolly P Huang, None, Silencing of the retinoid response gene TIG1 by promoter hypermethylation in nasopharyngeal carcinoma. International Journal of Cancer. ,vol. 113, pp. 386- 392 ,(2005) , 10.1002/IJC.20593
Hong Lok Lung, Arthur Kwok Leung Cheung, Josephine Mun Yee Ko, Yue Cheng, Eric J. Stanbridge, Maria Li Lung, Deciphering the molecular genetic basis of NPC through functional approaches. Seminars in Cancer Biology. ,vol. 22, pp. 87- 95 ,(2012) , 10.1016/J.SEMCANCER.2011.11.002
E W L Law, A K L Cheung, V I Kashuba, T V Pavlova, E R Zabarovsky, H L Lung, Y Cheng, D Chua, D Lai-wan Kwong, S W Tsao, T Sasaki, E J Stanbridge, M L Lung, Anti-angiogenic and tumor-suppressive roles of candidate tumor-suppressor gene, Fibulin-2, in nasopharyngeal carcinoma. Oncogene. ,vol. 31, pp. 728- 738 ,(2012) , 10.1038/ONC.2011.272
Arthur Kwok Leung Cheung, Hong Lok Lung, Siu Chun Hung, Evan Wai Lok Law, Yue Cheng, Wing Lung Yau, Dhinoth Kumar Bangarusamy, Lance D. Miller, Edison Tak-Bun Liu, Jian-Yong Shao, Chang-Wei Kou, Daniel Chua, Eugene R. Zabarovsky, Sai Wah Tsao, Eric J. Stanbridge, Maria Li Lung, Functional Analysis of a Cell Cycle–Associated, Tumor-Suppressive Gene, Protein Tyrosine Phosphatase Receptor Type G, in Nasopharyngeal Carcinoma Cancer Research. ,vol. 68, pp. 8137- 8145 ,(2008) , 10.1158/0008-5472.CAN-08-0904
Hong Lok Lung, Dhinoth Kumar Bangarusamy, Dan Xie, Arthur Kwok Leung Cheung, Yue Cheng, Mande Kuppusamy Kumaran, Lance Miller, Edison Tak-Bun Liu, Xin-Yuan Guan, Jonathan Shuntong Sham, Yan Fang, Liqiong Li, Nancy Wang, Alexey I Protopopov, Eugene R Zabarovsky, Sai Wah Tsao, Eric J Stanbridge, Maria Li Lung, None, THY1 is a candidate tumour suppressor gene with decreased expression in metastatic nasopharyngeal carcinoma Oncogene. ,vol. 24, pp. 6525- 6532 ,(2005) , 10.1038/SJ.ONC.1208812