作者: Laura Mansi , Antoine Thiery-Vuillemin , Thierry Nguyen , Fernando Bazan , Fabien Calcagno
DOI: 10.1517/14740330903530663
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摘要: Importance of the field: The development targeted anticancer therapies stems from advances in molecular biology. New agents range antibodies that form complexes with antigens on surface cancer cell to small molecules have been engineered block key enzymatic reactions. interaction antibody or drug its target inhibits pathways involved proliferation metastasis, activates leading death. Such constitute ideal pharmacological targets. Clinical benefits these novel therapeutic strategies are striking for patients metastatic diseases.Areas covered: This review analyses main toxicities among most common approved by FDA European Medicines Agency their clinical utilisation solid tumours treatment.What reader will gain: Here, toxicity and safety data new described. Data organised through t...