Silver‐Catalyzed Coupling of Two C sp 3H Groups and One‐Pot Synthesis of Tetrasubstituted Furans, Thiophenes, and Pyrroles
作者： Shuai Mao , Xue-Qing Zhu , Ya-Ru Gao , Dong-Dong Guo , Yong-Qiang Wang
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摘要: Silver-catalyzed coupling of two C sp(3)-H groups to form 1,4-diketones have been developed for the first time. The resultant ketones then undergo cyclization synthesize tetrasubstituted furans, thiophenes, and pyrroles from benzyl ketone derivatives in a one-pot reaction process. This highly-efficient synthetic method, which utilizes air as terminal oxidant readily accessible starting materials, displays wide substrate scope broad functional-group tolerance.
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