Further studies on prostaglandin E1-induced jejunal secretion of water and electrolytes in man, with special reference to the influence of ethacrynic acid, furosemide, and aspirin.
作者： Claude Matuchansky , Jean-Yves Mary , Jean-Jacques Bernier
DOI: 10.1016/S0016-5085(76)80201-6
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摘要: Perfusion studies were performed in 35 healthy volunteers to investigate further the secretory effect of prostaglandin E1 (PGE1), administered intraluminally, on human jejunum. A perfusion system with a proximal occluding balloon and continuous aspiration duodenal secretions was used. The influence PGE1 (0.9 μg per kg min) glucose, fluid, ion transport entirely reproducible throughout 6-hr experiment fully reversible 60 min after end administration. ethacrynic acid (EA), aspirin (two agents previously reported inhibit choleraic secretion), furosemide studied both basal jejunal absorption PGE1-induced secretion water electrolytes. EA (2.5 mg kg), lumen, significantly reduced (P
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