Breast Cancer Susceptibility Gene 1 (BRCA1) Is a Coactivator of the Androgen Receptor
作者： Wayne D. Tilley , Michael R. Stallcup , Grant Buchanan , Ryan A. Irvine , Gerhard A. Coetzee
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摘要: In the present study, role of BRCA1 in ligand-dependent androgen receptor (AR) signaling was assessed. transfected prostate and breast cancer cell lines, enhanced AR-dependent transactivation a probasin-derived reporter gene. The effects were mediated through NH2-terminal activation function (AF-1) receptor. Cotransfection p160 coactivators markedly potentiated BRCA1-mediated enhancement AR signaling. addition, shown to interact physically with both coactivator, glucocorticoid interacting protein 1. These findings suggest that may directly modulate and, therefore, have implications regarding proliferation normal malignant androgen-regulated tissues.
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