Activation-induced cell death: the controversial role of Fas and Fas ligand in immune privilege and tumour counterattack.
作者： Stephen Maher , Deirdre Toomey , Claire Condron , David Bouchier‐Hayes
DOI: 10.1046/J.1440-1711.2002.01068.X
关键词:
摘要: Activation-induced cell death (AICD) is the process by which cells undergo apoptosis in a controlled manner through interaction of factor and its receptor. Programmed can be induced number physiological pathological factors including Fas (CD95)-Fas ligand (FasL/CD95L) interaction, tumour necrosis (TNF), ceramide, reactive oxygen species (ROS). 48-kDa type I transmembrane protein that belongs to TNF/nerve growth receptor superfamily. FasL 40-kDa II TNF The with results series signal transductions initiate apoptosis. induction this termed AICD. Fas-FasL interactions have been shown play significant roles immune system homeostasis. In review involvement death, particular reference T cell, mechanism(s) they induce described. role AICD homeostasis controversy surrounding privilege, inflammation, so-called counterattack also discussed.
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