Lithium induces phosphoglucomutase activity in various tissues of rats and in bipolar patients.
作者： Péter Csutora , Árpád Karsai , Tamás Nagy , Bálint Vas , Gábor L. Kovács
DOI: 10.1017/S146114570500622X
关键词:
摘要: Phosphoglucomutase catalyses the reversible conversion of glucose-6-P and glucose-1-P. Lithium is a potent inhibitor phosphoglucomutase in vitro, however, it not known if was significantly inhibited by Li+ Li+-treated bipolar patients. Here, we demonstrate that inhibition chronic treatment causes alterations glucose-phosphate levels various tissues rats. Also, results compensatory elevation activity rat leukocytes isolated from The increase uninhibited patients due to increased expression PGM1 gene.
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