The diversity of seizures related to alcohol use. A study of consecutive patients.

摘要: The aims of this dissertation were to investigate alcohol-related seizures in clinical neurological practice. We wanted assess the extent problem, classify seizures, and methods improve diagnosis such seizures. propose an arbitrary but simple reproducible way diagnosing alcohol withdrawal Papers I II relate seizure classification problem relation level weekly pattern use. Paper III investigates performance various biological markers as aids IV explores pitfalls result interpretation for two detection CDT patients with disorders. V utility standard EEG identification Even though general consumption our region is low, every third patient epileptic leading hospitalisation had hazardous consumption.Evidence focal lesions or start was found a high proportion All secondarily generalized thus, we challenge establishment impression that vast majority are primarily generalized. Binge drinking (more than six drinks men four women, single occasion) common, little influence on susceptibility timing In contrast prior knowledge, some there no time lag from cessation occurrence seizure, falling intake levels demonstrated. This indicates state relative while still may be sufficient induce seizure. Carbohydrate-deficient transferring (CDT) most accurate biomarker use good adjunct its accuracy does not compete investigation. Generally poor should expected fertile women. Women enzyme-inducing antiepileptic drugs who drink seem at risk having false positive CDT. Other variables associated increased low body mass index, total outside normal range. A definitely abnormal suggests epilepsy symptomatic unrelated predictive value limited, typical post-ictal finding nevertheless low-amplitude record. best method work-up based thorough medical history. Alcohol Use Disorders Identification Test (AUDIT) provides reliable measure habits. supplement when doubt, if factors false-positive values appreciated. diagnostic limited.