Expression of a Functional Eotaxin (CC Chemokine Ligand 11) Receptor CCR3 by Human Dendritic Cells

摘要: Critical to the function of Ag-presenting dendritic cells (DCs) is their capacity migrate lymphoid organs and sites inflammation. A final stage development, termed maturation, yields DCs that are strong stimulators T cell-mediated immunity associated with a remodeling cell surface includes change in levels expression many molecules, including chemokine receptors. We show this study CCR3, receptor initially discovered on eosinophils, also expressed by human differentiate from blood monocytes, emigrate skin (epidermal dermal DCs), derived CD34+ hemopoietic precursors bone marrow, umbilical cord blood, cytokine-elicited peripheral leukapheresis. Unlike other receptors, such as CCR5 CCR7, CCR3 not dependent state maturation. All DC subsets contain large intracellular pool CCR3. The modulated following uptake particulate substances zymosan or latex beads. mediates vitro chemotactic responses known ligands, eotaxin eotaxin-2, because response these chemokines inhibited CCR3-specific mAbs. postulate may underlie situations where both eosinophils accumulate vivo, lesions patients Langerhans granulomatosis.