Neural consequences of sleep disordered breathing: the role of intermittent hypoxia.

摘要: Sleep disordered breathing is characterised by periodic breathing, episodes of hypoxia and repeated arousals from sleep; symptoms include excessive daytime sleepiness, impairment memory, learning attention. Recent evidence animal studies suggests that both intermittent sleep fragmentation can independently lead to neuronal defects in the hippocampus pre frontal cortex; areas known be closely associated with neural processing memory executive function. We have previously shown loss gray matter concentration within left (47). now confirmed extended this rinding 22 right handed, newly diagnosed male patients (mean (sd): age 51.8 (15.4) yrs, apnea / hypopnea index 53.1 (14.0) events/hr, minimum nocturnal oxygen saturation 75 (8.4) %) 17 controls matched for handedness. Voxel-based morphometry, an automated unbiased technique, was used characterise changes concentration. The magnetic resonance images were segmented grey determined voxel voxel. Analysis variance then preformed, adjusted overall image intensity, as a covariant. Additional deficit hippocampus, we found more extensive bilaterally parahippocampus. No additional focal lesions seen other brain regions. Based on our findings data human studies, speculate deficit, further such may cognitive dysfunction.