Divergent Effects of Serotonin on Coronary-Artery Dimensions and Blood Flow in Patients with Coronary Atherosclerosis and Control Patients
作者： Paolo Golino , Federico Piscione , James T. Willerson , Maurizio Cappelli-Bigazzi , Amelia Focaccio
DOI: 10.1056/NEJM199103073241001
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摘要: Abstract Background. Studies in animals have shown that serotonin constricts coronary arteries if the endothelium is damaged, but vitro studies revealed a vasodilating effect on isolated segments with an intact endothelium. To investigate of humans, we studied coronary-artery cross-sectional area and blood flow before after infusion seven patients angiographically normal artery disease. Methods. We measured by quantitative angiography intracoronary Doppler catheter. Measurements were obtained at base line during infusions (0.1, 1, 10 μg per kilogram body weight minute, for two minutes). repeated measurements ketanserin, antagonist receptors thought to block arterial wall not...
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