Biomarker discovery in ovarian cancer.

摘要: Ovarian cancer is a leading cause of gynecologic death among women. Tumors diagnosed early (in stage I) have cure rate approaching 90%. However, because specific symptoms and screening tools are lacking, most ovarian cancers very advanced when finally diagnosed. CA125 expression pelvic ultrasonography limited efficacy in screening, the search for new, complementary biomarkers continues. New technology research techniques allowed identification over 100 possible tumor markers, many which still being evaluated clinical relevance several entered trials. Here, we review methods biomarker discovery, address significance functions newly identified provide further insight into future biomarkers.