Causes of Genome Instability

摘要: Genomes are transmitted faithfully from dividing cells to their offspring. Changes that occur during DNA repair, chromosome duplication, and transmission or via recombination provide a natural source of genetic variation. They at low frequency because the intrinsic variable nature genomes, which we refer as genome instability. However, instability can be enhanced by exposure external genotoxic agents result cellular pathologies. We review causes well how it results in hyper-recombination, rearrangements, fragmentation loss, mainly mediated double-strand breaks single-strand gaps. Such events primarily associated with defects replication damage response, show high incidence repetitive DNA, non-B structures, DNA-protein barriers, highly transcribed regions. Identifying is crucial understanding dynamics cell proliferation its role cancer, aging, number rare diseases.