Laser 3D micro/nanofabrication of polymers for tissue engineering applications
作者： P. Danilevičius , S. Rekštytė , E. Balčiūnas , A. Kraniauskas , R. Širmenis
DOI: 10.1016/J.OPTLASTEC.2012.05.038
关键词:
摘要: Abstract In this work, we applied a constructed multi-photon polymerization system based on diode-pumped solid state femtosecond Yb:KGW laser used as pulsed irradiation light source (300 fs, 1030 nm, 200 kHz) in combination with large area high sample translation velocity (up to 300 mm/s) linear motor-driven stages (100×100×50 mm 3 ) designed for resolution and throughput 3D micro/nanofabrication. It enables rapid prototyping out of most polymers up cm scale sub-micrometer spatial resolution. This can be production three-dimensional artificial polymeric scaffolds cell growth expansion experiments well tissue engineering. Biocompatibilities different acrylate, hybrid organic–inorganic biodegradable materials were evaluated experimentally vitro . Various size form biocompatible photopolymers successfully fabricated having intricate geometry, thus demonstrating the potential method. Adult rabbit myogenic stem proliferation tests show applicable biomedical practice. Additionally, micromolding technique was multiplication adequate manufactured structures.
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