Serum insulin-like growth factor-II as a serologic marker of small hepatocellular carcinoma.

摘要: Objective Alpha-fetoprotein (AFP) is not a useful tumor marker for diagnosis of small hepatocellular carcinoma (HCC). There over-expression insulin-like growth factor (IGF)-II in HCC tissue. This study investigates the diagnostic application IGF-II HCC. Material and methods Serum levels AFP were determined 41 patients with cirrhotic (≤3 cm), sex- age-matched cirrhosis alone (LC), healthy adults. The optimal cut-off values diagnosing receiver operating characteristics (ROC) curve. Results Both higher than those LC or controls (each p=0.0001). lower (p=0.001). In patients, multivariate analysis indicated that both (odds ratio, 4.54; 95% confidence interval, 2.15–9.55; p=0.0001) 1.05; 1.01–1.08; p=0.003) found to be associated an in...