Cross-linking reagents for hemoglobin and hemoglobin products cross-linked therewith

摘要: A process for efficiently preparing bis-tetrameric hemoglobin in which the tetramers are specifically linked at predetermined sites on β-sub-units and themselves effectively bonded to prevent dissociation into dimeric αβ-hemoglobin sub-units therefrom is provided. The uses as cross-linking reagent a hexafunctional aromatic acyl phosphate containing amide groups, concept use has an excess of site-specific reacting namely six so that least four them will react site form product particular therapeutic interest.