Modulation of the BRCA1 Protein and Induction of Apoptosis in Triple Negative Breast Cancer Cell Lines by the Polyphenolic Compound Curcumin

摘要: In the current study, we sought to examine effects of curcumin in a specific type breast cancer called triple negative cancer. These cancers lack expression estrogen and progesterone receptors do not over-express HER2. Current treatment for is limited cytotoxic chemotherapy, upon relapse, there are any therapies currently available. We demonstrate here that bioactive food compound induces DNA damage cells association with phosphorylation, increased expression, cytoplasmic retention BRCA1 protein. addition, promotes apoptosis prevents anchorage-independent growth migration cells. Apoptosis modulation were observed non-transformed mammary epithelial cells, suggesting may have non-specific toxicity. This study suggests potentially analogues should be tested further context results novel, having never been previously reported, suggest could provide non-toxic therapy, which lead improved survival patients Curcumin studied this subset patients, whom options severely limited.