Detection of KPC Carbapenem-Hydrolyzing Enzymes in Enterobacter spp. from Brooklyn, New York

作者: Simona Bratu , David Landman , Maqsood Alam , Elaine Tolentino , John Quale

DOI: 10.1128/AAC.49.2.776-778.2005

关键词:

摘要: Enterobacter spp. are rarely resistant to carbapenems. In this report, one sp. isolate possessed blaKPC-3 and two blaKPC-2. For all three strains, the imipenem MICs were dependent on inoculum testing method; reported by clinical laboratories be carbapenem susceptible. Improved detection methods will necessary identify these enzymes.

参考文章(19)
C de Champs, C Henquell, D Guelon, D Sirot, N Gazuy, J Sirot, Clinical and bacteriological study of nosocomial infections due to Enterobacter aerogenes resistant to imipenem. Journal of Clinical Microbiology. ,vol. 31, pp. 123- 127 ,(1993) , 10.1128/JCM.31.1.123-127.1993
Erika Bruck, National Committee for Clinical Laboratory Standards. Pediatrics. ,vol. 65, pp. 187- 188 ,(1980)
David J. Weber, Ralph Raasch, William A. Rutala, Nosocomial Infections in the ICU Chest. ,vol. 115, pp. 34S- 41S ,(1999) , 10.1378/CHEST.115.SUPPL_1.34S
J. Quale, S. Bratu, D. Landman, R. Heddurshetti, Molecular Epidemiology and Mechanisms of Carbapenem Resistance in Acinetobacter baumannii Endemic in New York City Clinical Infectious Diseases. ,vol. 37, pp. 214- 220 ,(2003) , 10.1086/375821
Hesna Yigit, Anne Marie Queenan, Gregory J. Anderson, Antonio Domenech-Sanchez, James W. Biddle, Christine D. Steward, Sebastian Alberti, Karen Bush, Fred C. Tenover, Novel Carbapenem-Hydrolyzing β-Lactamase, KPC-1, from a Carbapenem-Resistant Strain of Klebsiella pneumoniae Antimicrobial Agents and Chemotherapy. ,vol. 45, pp. 1151- 1161 ,(2001) , 10.1128/AAC.45.4.1151-1161.2001
Hesna Yigit, Anne Marie Queenan, J. Kamile Rasheed, James W. Biddle, Antonio Domenech-Sanchez, Sebastian Alberti, Karen Bush, Fred C. Tenover, Carbapenem-resistant strain of Klebsiella oxytoca harboring carbapenem-hydrolyzing beta-lactamase KPC-2. Antimicrobial Agents and Chemotherapy. ,vol. 47, pp. 3881- 3889 ,(2003) , 10.1128/AAC.47.12.3881-3889.2003
Joseph W. Chow, David M. Shlaes, Imipenem resistance associated with the loss of a 40 kDa outer membrane protein in Enterobacter aerogenes Journal of Antimicrobial Chemotherapy. ,vol. 28, pp. 499- 504 ,(1991) , 10.1093/JAC/28.4.499
Charléric Bornet, Anne Davin-Regli, Claude Bosi, Jean-Marie Pages, Claude Bollet, Imipenem resistance of enterobacter aerogenes mediated by outer membrane permeability. Journal of Clinical Microbiology. ,vol. 38, pp. 1048- 1052 ,(2000) , 10.1128/JCM.38.3.1048-1052.2000
B A Rasmussen, K Bush, D Keeney, Y Yang, R Hare, C O'Gara, A A Medeiros, Characterization of IMI-1 beta-lactamase, a class A carbapenem-hydrolyzing enzyme from Enterobacter cloacae. Antimicrobial Agents and Chemotherapy. ,vol. 40, pp. 2080- 2086 ,(1996) , 10.1128/AAC.40.9.2080