Age does not influence acute aspirin-induced gastric mucosal damage

摘要: Gastroduodenal ulceration and complications occur more commonly in elderly patients consuming aspirin other nonsteroidal antiinflammatory drugs than younger cohorts. To test the hypothesis that gastroduodenal mucosa of is sensitive to drug damage, acetylsalicylic acid low (325 mg) high (1300 doses was administered on separate days 10 (median age, 67.5; range, 60-74 years) young 24.5; 19-30 healthy, male volunteer subjects. mucosal damage assessed 2 hours after dosage by video-endoscopic techniques. At conclusion study, videotapes all procedures were randomly evaluated two endoscopists blinded subject identification or study sequence. Endoscopically observed lesions counted duodenum, gastric antrum, body. Aspirin dose-related severe stomach duodenum. There no significant differences total lesion counts between age groups. In addition, median pH tissue 6-ketoprostaglandin F1 alpha content These data suggest not a factor determining extent acutely aspirin-induced damage.