An immunohistochemical study of the c-erbB-2 oncogene product in intraductal mucin-hypersecreting neoplasms and in ductal cell carcinomas of the pancreas.

作者: Kennichi Satoh , Hironobu Sasano , Tooru Shimosegawa , Masaru Koizumi , Tadashi Yamazaki

DOI: 10.1002/1097-0142(19930701)72:1<51::AID-CNCR2820720112>3.0.CO;2-O

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摘要: Background. Intraductal mucin-hypersecreting neoplasm of the pancreas (IMHN) is a unique tumor that has tendency to spread intraductally. The clinical outcome IMHN generally far better than pancreatic ductal cell carcinoma. Because presence various atypia within same tumor, it sometimes difficult make an accurate histopathologic diagnosis and, therefore, predict its biologic behavior. It been shown overexpression c-erbB-2 protein in breast cancer with lymph node metastases related poor prognosis. Overexpression reported as infrequent event carcinoma, but little known case IMHN. Methods. expression was immunohistochemically investigated formaldehyde-fixed, paraffin-embedded tissues 17 cases IMHN, and 14 carcinoma (8 metastasis), using polyclonal monoclonal c-erB-2(p185) antibodies by avidinbiotin method. Results. Both showed similar immunostaining for product. product observed frequently (13/17), especially moderate- high-grade (12/12), whereas detected only 1 (1/14). Among eight metastases, over-expression metastatic lesions two, one whose primary also overexpressed oncogene product. Conclusions. These observations suggest genetic pathogenesis IMHN. Cancer 1993; 72:51–6.

参考文章(40)
D. Chin, R. Ortiz, J. W. Bacus, D. S. Weinberg, S. S. Bacus, S. G. Ruby, HER-2/neu oncogene expression and proliferation in breast cancers. American Journal of Pathology. ,vol. 137, pp. 103- 111 ,(1990)
Fabienne Rickaert, Michel Cremer, Jacques Devière, Lourdes Tavares, Jean Pierre Lambilliotte, Sören Schröder, Ditmar Wurbs, Günter Klöppel, None, Intraductal mucin-hypersecreting neoplasms of the pancreas. A clinicopathologic study of eight patients. Gastroenterology. ,vol. 101, pp. 512- 519 ,(1991) , 10.1016/0016-5085(91)90032-G
Fukuji Mochizuki, Tooru Shimosegawa, Tadashi Yamazaki, Kennichi Satoh, Takayoshi Toyota, Masaru Koizumi, Takashi Sawai, The point mutation of c-Ki-ras at codon 12 in carcinoma of the pancreatic head region and in intraductal mucin-hypersecreting neoplasm of the pancreas International Journal of Pancreatology. ,vol. 14, pp. 135- 143 ,(1993) , 10.1007/BF02786119
W J Gullick, P Kelly, Sainsbury, C Wright, A L Harris, B Angus, J Cairns, S Nicholson, C H Horne, Expression of c-erbB-2 Oncoprotein: A Prognostic Indicator in Human Breast Cancer Cancer Research. ,vol. 49, pp. 2087- 2090 ,(1989)
B A Gusterson, R D Gelber, A Goldhirsch, K N Price, J Säve-Söderborgh, R Anbazhagan, J Styles, C M Rudenstam, R Golouh, R Reed, Prognostic importance of c-erbB-2 expression in breast cancer. International (Ludwig) Breast Cancer Study Group. Journal of Clinical Oncology. ,vol. 10, pp. 1049- 1056 ,(1992) , 10.1200/JCO.1992.10.7.1049
Amanda H. McCann, Peter A. Dervan, Desmond N. Carney, Brendan M. J. Tobin, Myra O'Regan, Mary B. Codd, William J. Gullick, Prognostic significance of c-erbB-2 and estrogen receptor status in human breast cancer. Cancer Research. ,vol. 51, pp. 3296- 3303 ,(1991)
S Toikkanen, H Helin, J Isola, H Joensuu, Prognostic significance of HER-2 oncoprotein expression in breast cancer: a 30-year follow-up. Journal of Clinical Oncology. ,vol. 10, pp. 1044- 1048 ,(1992) , 10.1200/JCO.1992.10.7.1044
DM Barnes, GA Lammie, RR Millis, WL Gullick, DS Allen, DG Altman, An immunohistochemical evaluation of c- erbB-2 expression in human breast carcinoma British Journal of Cancer. ,vol. 58, pp. 448- 452 ,(1988) , 10.1038/BJC.1988.238
Alan L. Schechter, David F. Stern, Lalitha Vaidyanathan, Stuart J. Decker, Jeffrey A. Drebin, Mark I. Greene, Robert A. Weinberg, The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen. Nature. ,vol. 312, pp. 513- 516 ,(1984) , 10.1038/312513A0
Ian P. Corbett, James A. Henry, Brian Angus, Caroline J. Watchorn, Linda Wilkinson, Colm Hennessy, William J. Gullick, Nadia L. Tuzi, Felicity E. B. May, Bruce R. Westley, Charles H. W. Horne, NCL‐CB11, a new monoclonal antibody recognizing the internal domain of the c‐erbB‐2 oncogene protein effective for use on formalin‐fixed, paraffin‐embedded tissue The Journal of Pathology. ,vol. 161, pp. 15- 25 ,(1990) , 10.1002/PATH.1711610105