Early B-cell precursors in scid mice: Normal numbers of cells transformable with abelson murine leukemia virus (A-MuLV)

摘要: Abstract scid mice lack detectable B and T lymphocytes; there are no typical pre-B cells as defined by cμ surface markers in their bone marrow thymus contains only 1% of the normal number cells. In these characters seem to lymphoid stem However, some have serum immunoglobulin others develop thymomas; both observations indicate that block development is not absolute. To determine whether any B-cell precursors, we looked for ability be transformed Abelson murine leukemia virus (A-MuLV). Surprisingly, contain many precursors transformable with A-MuLV control mice. Cell-surface specific were detected on A-MuLV-transformed mice, indicating belong lineage. Interestingly, same undetectable nontransformed We conclude from results numbers early but differentiation into functional severely impaired.