Leptin is able to stimulate pancreatic enzyme secretion via activation of duodeno-pancreatic reflex and CCK release.

摘要: Leptin, 16- kDa protein produced and secreted from white adipocytes is known to regulate food intake energy expenditure. Leptin receptors have been detected in the pancreas it has shown that systemic application of this diminished postprandial pancreatic secretion. also stomach released into gastrointestinal lumen but implication luminal leptin regulation enzyme secretion not elucidated. The aim our study was evaluate effects intraduodenal (i.d.) administration on assess involvement afferent nerves CCK above effects. secretory studies were carried out anaesthetized Wistar rats with acute fistulae. administered animals at doses 0.1 1.0 or 10.0 microg/kg i.d. Tarazepide (2.5 mg/kg i.d.), a CCK(1) receptor antagonist, given prior leptin. Rats capsaicin deactivated sensory used part study. Samples juice taken 15 min intervals measure volume flow amylase concentrations. plasma level measured by radioimmunoassay (RIA) following rats. Intraduodenal (1.0 microg/kg) fasted significantly dose-dependently increased outputs. Pancreatic responses totally abolished deactivation pretreatment tarazepide. Under basal conditions averaged about 15.46 +/- 1,4 pg/ml. Exogenous leptin, intact capsaicin-deactivated resulted dose-dependent rise level, reaching highest value dose We conclude stimulates effect could be related stimulation release activation duodeno-pancreatic reflexes.