DISQUISITIONS ON ORIGINAL ANTIGENIC SIN : I. EVIDENCE IN MAN

摘要: When primary immunity is boosted not by the homologous but a crossreacting vaccine, newly formed antibodies react better with antigen than actually eliciting response. This phenomenon bears name of Original Antigenic Sin (1). It shown that number antibody molecules produced against original and vaccinating same; each these capable reacting both antigens; activity an antiserum can be completely absorbed either antigen; residual adsorbed-dissociated fractions exhibit same relative affinities towards two antigens as did native serum; that, unlike standard secondary responses, population characterizing homogeneous; molecule has lower equilibrium constant (i.e. higher avidity) stimulating present response; all constants are typical antibody. concluded partial anamnestic response, related sector only originally primed cells which destined to produce cross-reacting A hypothesis developed according basic difference between reactivity rests on presence trapping mechanism allows production doses antigen. Such cross-trapping antigens, thus preventing response allowing manifestations Sin.