Aneuploidy characterizes adjacent non-malignant mucosa of ulcerative colitis-associated but not sporadic colorectal carcinomas: a matched-pair analysis.
作者： Karl-Frederick Meyer , Sarah Louise Nause , Sandra Freitag-Wolf , Stefan Krüger , Hans-Peter Bruch
DOI: 10.3109/00365521.2013.783103
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摘要: Abstract Introduction. Aneuploidy has been suggested as independent prognostic marker in ulcerative colitis (UC) patients for developing UC-associated colorectal carcinomas (UCCs). UCCs are associated with a poorer prognosis and more frequently present synchronous when compared sporadic (SCCs). The authors therefore investigated if the adjacent non-malignant mucosa of aneuploid SCCs shows differences regarding frequency aneuploidy this is histomorphological alterations. Methods. Primary tumors 25 20 were selected showing exclusively DNA patterns matching stemlines. UCCs' (n = 82) SCCs' 40) evaluated histopathology assessed ploidy status by image cytometry. Results. showed dysplasia 31.7% 89%. In contrast, revealed no an...
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