Diagnostic value of DNA image cytometry in ulcerative colitis.

摘要: The increased risk of colorectal cancer in patients with extensive, long-standing ulcerative colitis is well established. interpretation dysplasia as the common precursor lesion is, however, subject to inter- and intraobserver variation. histologic diagnosis particularly difficult presence acute inflammation. Therefore, analysis ploidy patterns might be a more objective diagnostic tool. In present study, correlation colonic mucosa was evaluated absence Image cytometry performed on 561 fixed, paraffin-embedded tissue specimens from 67 colitis. Twenty had extensive disease, including eight whom associated cancer. Dysplasia only found or significantly often diagnosed case concomitant On other hand, aneuploid were shown occur independent inflammatory activity. Aneuploidy all carcinomas 46.2% dysplasia. Moreover, aneuploidy detectable four 12 samples low-grade one devoid any dysplastic alteration. Ulcerative plus probably represent subgroup that at higher developing than alone. All all, image instrumental identifying neoplastic lesions even cases activity regenerative change.