The P-glycoprotein homologues of Plasmodium falciparum: Are they involved in chloroquine resistance?
作者： A.F. Cowman
DOI: 10.1016/0169-4758(91)90197-V
关键词:
摘要: Chloroquine has been the mainstay of antimalarial chemotherapy but rapid spread resistance to this important drug now compromised its efficacy. The mechanism chloroquine not known recent evidence from Plasmodium falciparum, causative agent most severe form human malaria, suggested similarities multidrug phenotype (MDR) mammalian tumour cells which is mediated by a protein molecule termed P-glycoprotein. Two mdr genes (pfmdr1 and pfmdr2) encoding P-glycoprotein homologues have identified in P. falciparum one these (pfmdr1) several alleles that linked phenotype. In contrast analysis genetic cross between chloroquine-resistant -sensitive are linked. This review outlines with MDR explores possible role pfmdr genes.
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