作者: Moneeb Ehtesham , Reid C. Thompson
关键词:
摘要: Malignant glioma remains one of the most intractable human cancers principally due to highly infiltrative nature these neoplasms. The use neural precursor cells (NPC) has received considerable attention based on their ability selectively migrate towards disseminated areas tumor in vivo and described deliver tumor-directed therapies specifically infiltrating cells. Fundamental optimizing for potential clinical translation is development an understanding regarding biologic cues that govern foci. To this end, paper we detail NPC selected double-expression glial-precursor marker A2B5 cell-surface chemokine receptor, CXCR4, demonstrate enhanced vitro gliomadirected tropism. These findings relevance markers phenotypic segregation optimally tumor-tropic sub-population as a means enhancing NPC-based therapeutic strategies treatment glioma.