CXCR4-Expressing Glial Precursor Cells Demonstrate Enhanced Migratory Tropism for Glioma

作者: Moneeb Ehtesham , Reid C. Thompson

DOI: 10.4236/JCT.2012.36142

关键词:

摘要: Malignant glioma remains one of the most intractable human cancers principally due to highly infiltrative nature these neoplasms. The use neural precursor cells (NPC) has received considerable attention based on their ability selectively migrate towards disseminated areas tumor in vivo and described deliver tumor-directed therapies specifically infiltrating cells. Fundamental optimizing for potential clinical translation is development an understanding regarding biologic cues that govern foci. To this end, paper we detail NPC selected double-expression glial-precursor marker A2B5 cell-surface chemokine receptor, CXCR4, demonstrate enhanced vitro gliomadirected tropism. These findings relevance markers phenotypic segregation optimally tumor-tropic sub-population as a means enhancing NPC-based therapeutic strategies treatment glioma.

参考文章(17)
Tanya S. Surawicz, Faith Davis, Sally Freels, Edward R. Laws Jr., Herman R. Menck, Brain tumor survival: results from the National Cancer Data Base. Journal of Neuro-oncology. ,vol. 40, pp. 151- 160 ,(1998) , 10.1023/A:1006091608586
Sara Benedetti, Barbara Pirola, Bianca Pollo, Lorenzo Magrassi, Maria Grazia Bruzzone, Dorotea Rigamonti, Rossella Galli, Silvia Selleri, Francesco Di Meco, Claudio De Fraja, Angelo Vescovi, Elena Cattaneo, Gaetano Finocchiaro, Gene therapy of experimental brain tumors using neural progenitor cells Nature Medicine. ,vol. 6, pp. 447- 450 ,(2000) , 10.1038/74710
Shugang Ge, Steve Dudas, Jorge A. Gutiérrez, Sandra A. Rempel, Identification and localization of the cytokine SDF1 and its receptor, CXC chemokine receptor 4, to regions of necrosis and angiogenesis in human glioblastoma Clinical Cancer Research. ,vol. 6, pp. 102- 111 ,(2000)
Moneeb Ehtesham, Peter Kabos, Keith L Black, John S Yu, Use of neural stem cells as therapeutic vehicles for the treatment of malignant glioma. Expert Review of Neurotherapeutics. ,vol. 3, pp. 883- 895 ,(2003) , 10.1586/14737175.3.6.883
K. S. Aboody, A. Brown, N. G. Rainov, K. A. Bower, S. Liu, W. Yang, J. E. Small, U. Herrlinger, V. Ourednik, P. McL. Black, X. O. Breakefield, E. Y. Snyder, Neural stem cells display extensive tropism for pathology in adult brain: evidence from intracranial gliomas. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 97, pp. 12846- 12851 ,(2000) , 10.1073/PNAS.97.23.12846
M Ehtesham, J A Winston, P Kabos, R C Thompson, CXCR4 expression mediates glioma cell invasiveness. Oncogene. ,vol. 25, pp. 2801- 2806 ,(2006) , 10.1038/SJ.ONC.1209302
Peter Kabos, Yasuharu Akasaki, Keith L. Black, Xiangpeng Yuan, Gentao Liu, Nancy H.C. Chung, John S. Yu, Moneeb Ehtesham, Glioma Tropic Neural Stem Cells Consist of Astrocytic Precursors and Their Migratory Capacity Is Mediated by CXCR4 Neoplasia. ,vol. 6, pp. 287- 293 ,(2004) , 10.1593/NEO.3427
Khubaib Y. Mapara, Charles B. Stevenson, Reid C. Thompson, Moneeb Ehtesham, Stem cells as vehicles for the treatment of brain cancer. Neurosurgery Clinics of North America. ,vol. 18, pp. 71- 80 ,(2007) , 10.1016/J.NEC.2006.10.001
Fran�oise Lazarini, To Nam Tham, Philippe Casanova, Fernando Arenzana-Seisdedos, Monique Dubois-Dalcq, Role of the ?-chemokine stromal cell-derived factor (SDF-1) in the developing and mature central nervous system Glia. ,vol. 42, pp. 139- 148 ,(2003) , 10.1002/GLIA.10139