ARID1A mutations in endometriosis-associated ovarian carcinomas.
作者： Kimberly C Wiegand , Sohrab P Shah , Osama M Al-Agha , Yongjun Zhao , Kane Tse
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摘要: Background Ovarian clear-cell and endometrioid carcinomas may arise from endometriosis, but the molecular events involved in this transformation have not been described. Methods We sequenced whole transcriptomes of 18 ovarian 1 carcinoma cell line found somatic mutations ARID1A (the AT-rich interactive domain 1A [SWI-like] gene) 6 samples. encodes BAF250a, a key component SWI–SNF chromatin remodeling complex. an additional 210 second measured BAF250a expression by means immunohistochemical analysis 455 carcinomas. Results were seen 55 119 (46%), 10 33 (30%), none 76 high-grade serous Seventeen had two each. Loss protein correlated strongly with c...
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