Atheroprotection with amlodipine: cells to lesions and the PREVENT trial. Prospective Randomized Evaluation of the Vascular Effects of Norvasc Trial.

摘要: Oxidized lipid and calcium regulatory abnormalities appear to play important roles in early atherogenesis secondary cholesterol enrichment of the cell membrane endothelial arterial smooth muscle cells (SMCs). However, link between two is poorly understood. The findings reviewed here demonstrate that amlodipine has membrane-modifying antioxidant actions at level addition its classical channel blocking properties. These multiple pharmacologic may explain cellular mechanisms atheroprotective effects spontaneous accelerated atherosclerotic syndromes. Recent animal model studies have demonstrated inhibits progression lesions protects against restenosis after angioplasty. Amlodipine cholesterol-induced increase permeability SMCs, been shown repair SMC structure. data also a marked action bilayers enriched with polyunsaturated fatty acids. these models only: efficacy atheroprotection humans cannot be predicted. PREVENT trial therefore launched examine potential lesion development ischemic heart disease prevention