Bioinformatics insight into glycosyltransferase gene expression in gastric cancer: POFUT1 is a potential biomarker
作者： Shuang Dong , Zhe Wang , Binbin Huang , Junjie Zhang , Yanli Ge
DOI: 10.1016/J.BBRC.2016.12.172
关键词:
摘要: Abstract Aberrant glycosylation plays an important role in the progression of gastric cancer. Although many enzymes are involved glycoconjugate synthesis, little information is known about glycosyltransferase (GT)’s alteration To give insight into differential expression GTs as obtained from TCGA database, bioinformatics analysis 415 cancer samples and 35 normal was performed. Using a 0.6-fold change threshold to compare GT tissues, it noted that 36 were upregulated including POFUT1 30 GTs downregulated tissues (P
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Jonathan J. Lyons, Joshua D. Milner, Sergio D. Rosenzweig, Glycans Instructing Immunity: The Emerging Role of Altered Glycosylation in Clinical Immunology Frontiers in Pediatrics. ,vol. 3, pp. 54- 54 ,(2015) , 10.3389/FPED.2015.00054
Simone Albrecht, Louise Unwin, Mohankumar Muniyappa, Pauline M Rudd, None, Glycosylation as a marker for inflammatory arthritis Cancer Biomarkers. ,vol. 14, pp. 17- 28 ,(2014) , 10.3233/CBM-130373
BINBIN HUANG, QIONG WU, YANLI GE, JUNJIE ZHANG, LONGE SUN, YUNYUN ZHANG, LIU FU, JUANJUAN FAN, ZHIRONG WANG, Expression of N-acetylglucosaminyltransferase V in gastric cancer correlates with metastasis and prognosis International Journal of Oncology. ,vol. 44, pp. 849- 857 ,(2014) , 10.3892/IJO.2014.2248
Piotr Laidler, Anna Lityńska, Dorota Hoja-Łukowicz, Maria Łabędz, Małgorzata Przybyło, Dorota Ciołczyk-Wierzbicka, Ewa Pocheć, Ewa Trębacz, Elżbieta Kremser, Characterization of glycosylation and adherent properties of melanoma cell lines. Cancer Immunology, Immunotherapy. ,vol. 55, pp. 112- 118 ,(2006) , 10.1007/S00262-005-0019-4
Cuijuan Qian, Fuqiang Liu, Bei Ye, Xin Zhang, Yong Liang, Jun Yao, Notch4 promotes gastric cancer growth through activation of Wnt1/β-catenin signaling Molecular and Cellular Biochemistry. ,vol. 401, pp. 165- 174 ,(2015) , 10.1007/S11010-014-2304-Z
James W Dennis, Maria Granovsky, Charles E Warren, Glycoprotein glycosylation and cancer progression Biochimica et Biophysica Acta. ,vol. 1473, pp. 21- 34 ,(1999) , 10.1016/S0304-4165(99)00167-1
Maja N. Christiansen, Jenny Chik, Ling Lee, Merrina Anugraham, Jodie L. Abrahams, Nicolle H. Packer, Cell surface protein glycosylation in cancer. Proteomics. ,vol. 14, pp. 525- 546 ,(2014) , 10.1002/PMIC.201300387
F. Demichelis, S. R. Setlur, S. Banerjee, D. Chakravarty, J. Y. H. Chen, C. X. Chen, J. Huang, H. Beltran, D. A. Oldridge, N. Kitabayashi, B. Stenzel, G. Schaefer, W. Horninger, J. Bektic, A. M. Chinnaiyan, S. Goldenberg, J. Siddiqui, M. M. Regan, M. Kearney, T. D. Soong, D. S. Rickman, O. Elemento, J. T. Wei, D. S. Scherr, M. A. Sanda, G. Bartsch, C. Lee, H. Klocker, M. A. Rubin, Identification of functionally active, low frequency copy number variants at 15q21.3 and 12q21.31 associated with prostate cancer risk Proceedings of the National Academy of Sciences of the United States of America. ,vol. 109, pp. 6686- 6691 ,(2012) , 10.1073/PNAS.1117405109
Alex D. Shaw, Yash Tiwari, Warren Kaplan, Anna Heath, Philip B. Mitchell, Peter R. Schofield, Janice M. Fullerton, Characterisation of Genetic Variation in ST8SIA2 and Its Interaction Region in NCAM1 in Patients with Bipolar Disorder PLoS ONE. ,vol. 9, pp. e92556- ,(2014) , 10.1371/JOURNAL.PONE.0092556
Marco Trinchera, Nadia Malagolini, Mariella Chiricolo, Donatella Santini, Francesco Minni, Anna Caretti, Fabio Dall’Olio, The biosynthesis of the selectin-ligand sialyl Lewis x in colorectal cancer tissues is regulated by fucosyltransferase VI and can be inhibited by an RNA interference-based approach The International Journal of Biochemistry & Cell Biology. ,vol. 43, pp. 130- 139 ,(2011) , 10.1016/J.BIOCEL.2010.10.004