Expression of N-acetylglucosaminyltransferase V in gastric cancer correlates with metastasis and prognosis

摘要: N-acetylglucosaminyltransferase V (GnT-V) is an enzyme that catalyzes β1-6 branching of N-acetylglucosamine on asparagine (N)-linked oligosaccharides (N-glycan) cell proteins and the dysfunction which a common feature various carcinomas. Nevertheless, role GnT-V remains controversial. Therefore, clinical implication expression may differ in each cancer type. The status patients with gastric has not been studied extensively. In present study, we examined specimen both at protein mRNA levels. We compared pathologic variables. Kaplan-Meier survival curves were generated to show cause-specific survival. Furthermore, small interfering RNA was devised downregulate SGC7901 BGC 823 cells. characterized function by proliferation invasiveness analysis. Analysis revealed correlated tumor grade stage. overall time positive significantly shorter than negative expression. Moreover, downregulation resulted decrease cells accompanied morphological change. This supports correlates metastasis prognosis cancer. These results contribute new insight into underlying molecular mechanisms regulation potential translational applications.