Regulation of N-acetylglucosaminyltransferase V and Asn-linked oligosaccharide β(1,6) branching by a growth factor signaling pathway and effects on cell adhesion and metastatic potential

摘要: Recent evidence demonstrates that the changes in size of N-linked oligosaccharides correlate with cell transformation and tumorigenicity are due at least part to regulation expression a glycosyltransferase involved branching structures, N-acetylglucosaminyltransferase V or GlcNAc-T V. Studies have shown increases after oncogenic most likely caused by direct effects on promoter Ets family transcriptional activators, which up-regulated cellular proliferation signaling pathway. This pathway begins growth factor receptors activate tyrosine kinases surface proceeds through src, ras, raf. Additional for association between will be presented, as well discussion β(1,6) several phenotypes oncogenically transformed cells, including metastatic potential.