Expression of N-acetylglucosaminyltransferase V in colorectal cancer correlates with metastasis and poor prognosis.
作者： Toshiyuki Kabuto , Osamu Ishikawa , Eiji Miyoshi , Masao Kameyama , Naoyuki Taniguchi
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摘要: N-Acetylglucosaminyltransferase V (GnT-V) is an enzyme that catalyzes beta 1-6 branching of N-acetylglucosamine on asparagine-linked oligosaccharides cell proteins. Metastatic potential various cancer cells has been shown to correlate with increase GnT-V activity and concomitant N-acetylglucosamine. However, protein expression in human tissue its clinical significance have not yet demonstrated. To clarify the possible relationship between metastasis colorectal cancer, was studied using surgically resected specimens. We established a monoclonal antibody against performed immunohistochemical analysis 103 cases. Of cases, 26 cases (25.2 %) showed specific tissues. The significantly correlated distant (P < 0.05, chi2 test). Overall 5-year survival rate 52.8% for GnT-V-positive patients 81.7% GnT-V-negative 0.01, Log-rank direct evidence cancer. Screening may provide useful information prognosis postoperative patients.
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