Use of a ray-based reconstruction algorithm to accurately quantify preclinical microSPECT images

摘要: This work aimed to measure the in vivo quantification errors obtained when ray-based iterative reconstruction is used micro–singlephoton emission computed tomography (SPECT). was investigated with an extensive phantom-based evaluation and two typical studies using 99m Tc 111 In, measured on a commercially available cadmium zinc telluride (CZT)-based small-animal scanner. Iterative implemented GPU ray tracing, including (1) scatter correction, (2) tomography– based attenuation (3) resolution recovery, (4) edge-preserving smoothing. It validated National Electrical Manufacturers Association (NEMA) phantom. The error determined for radiotracers: [ Tc]DMSA naive mice (n 5 10 kidneys) In]octreotide 6) inoculated xenograft neuroendocrine tumor (NCI-H727). energy 5.3% 140.51 keV ( Tc), 4.8% 171.30 keV, 3.3% 245.39 In). For Tc, uncorrected of 28 6 3% reduced 8 3%. reduces from 26 14% 22%. Tc-dimercaptosuccinic acid ([ Tc]DMSA) 16.2 2.8% 20.3 2.1% 16.7 610.1% 2.2 10.6% In]octreotide. Absolute quantitative SPECT possible without explicit system matrix measurements. An absolute smaller than 5% achieved exemplified both