Amplification of 1q32.1 Refines the Molecular Classification of Endometrial Carcinoma
作者： Jeroen Depreeuw , Ellen Stelloo , Elisabeth M Osse , Carien L Creutzberg , Remi A Nout
DOI: 10.1158/1078-0432.CCR-17-0566
关键词:
摘要: Purpose: Molecular classification of endometrial cancer identified distinct molecular subgroups. However, the largest subset cancers remains poorly characterized and is referred to as "nonspecific profile" (NSMP) subgroup. Here, we aimed at refining this subgroup by profiling somatic copy-number aberrations (SCNAs).Experimental Design: SCNAs were analyzed in 141 using whole-genome SNP arrays pooled with 361 from The Cancer Genome Atlas. Genomic Identification Significant Targets (GISTIC) statistically enriched penalized Cox regression assessed survival effects. prognostic significance relevant was validated multiplex ligation-dependent probe amplification 840 PORTEC-1/2 trials. Copy-number status genes correlated gene expression identify potential drivers. One plausible oncogene vitro antisense oligonucleotide-based strategy.Results: affecting chromosome 1q32.1 significantly worse relapse-free (RFS) NSMP (HR, 2.12; 95% CI, 1.26-3.59; P = 0.005). This effect replicated 2.34; 1.17-4.70; 0.017). A new including improved risk prediction recurrence. MDM4 strongly amplification. Silencing inhibited cell growth lines carrying amplification, but not those without Vice versa, increasing nonamplified stimulated proliferation.Conclusions: a marker for cancers, We functionally oncogenic driver region. Clin Res; 23(23); 7232-41. ©2017 AACR.
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