The Role of Cytokines in the Fibrotic Responses in Crohn’s Disease

摘要: Crohn's disease (CD) is an idiopathic disorder of the gut thought to be caused by a combination environmental and genetic factors in susceptible individuals. It characterised chronic transmural inflammation terminal ileum colon, with typical lesions. Complications, including fibrosis, mean that between 40% 70% patients require surgery first 10 years after diagnosis. Presently, there no evidence current therapies which dampen modulate or reverse intestinal fibrosis. In this review we focus on cytokines may lead fibrosis stenosis, contribution experimental models understanding treatment