Breaking the Itch-Scratch Cycle: Topical Options for the Management of Chronic Cutaneous Itch in Atopic Dermatitis.

摘要: Chronic itch is an unpleasant sensation that triggers a desire to scratch lasts for six weeks or more. It major diagnostic symptom of myriad diseases, including atopic dermatitis which it the most prominent feature. can be hugely debilitating sufferer, damaging in terms both monetary cost treatment and its socioeconomic effects, few options exist adequately control it. Corticosteroids remain first line strategy dermatitis, but due risks associated with long-term use corticosteroids, drawbacks other topical such as calcineurin inhibitors capsaicin, management are efficacious used indefinitely needed. In this review, we detail pathophysiology chronic pruritus, key features, disease commonly We also assess role skin components maintaining healthy barrier function, thus reducing dryness sensation. Lastly, briefly examples pruritus indefinitely, overcoming risk corticosteroids.