Myelin protein zero and membrane adhesion

摘要: Protein zero (P0) is a member of the immunoglobulin gene superfamily (IgCAM) that expressed at high levels in myelinated vertebrates central (fish and amphibia) peripheral (all species) myelin. This glycoprotein major adhesive component myelin, where it mediates self-adhesion Schwann cell plasma membrane. Although expression P0 naturally limited to cells, molecular mechanisms P0-mediated adhesion can be considered general "obligatory" because, when variety lines, induces strong intercellular adhesion. Modeling studies, X-ray crystallographic analysis, experimental site-directed mutagenesis have provided excellent working models for understanding how atomic level. These remain experimentally tested. However, humans, certain mutations produce dysmyelinating disease, possibly due disruptions predicted lattice.