The impact of helminths on the response to immunization and on the incidence of infection and disease in childhood in Uganda: design of a randomized, double-blind, placebo-controlled, factorial trial of deworming interventions delivered in pregnancy and early childhood [ISRCTN32849447].

摘要: BACKGROUND: Helminths have profound effects on the immune response, allowing long-term survival of parasites with minimal damage to host. Some these "spill-over", altering responses non-helminth antigens or allergens. It is suggested that this may lead impaired immunizations and infections, while conferring benefits against inflammatory in allergic autoimmune disease. These might develop utero, through exposure maternal helminth direct later life. PURPOSE: To determine helminths their treatment pregnancy young children immunological disease outcomes childhood. METHODS: The trial has three randomized, double-blind, placebo-controlled interventions at two times, people: a pregnant woman her child. Pregnant women are randomized albendazole placebo praziquantel placebo. At age 15 months three-monthly placebo, continue five years. proposed designation for sequence 2 x 2(x2) factorial design. Children immunized BCG polio, Diphtheria, tetanus, Pertussis, Haemophilus, hepatitis B measles. Primary tetanus toxoid whole blood cytokine assays antibody one, years age. incidence malaria, pneumonia, diarrhoea, tuberculosis, measles, vertical HIV transmission, atopic episodes, measured clinic visits twice-monthly home visits. Effects anaemia, growth intellectual development also assessed. CONCLUSION: This trial, novel design comprising related offspring, first examine early childhood immunological, infectious outcomes. results will enhance understanding both detrimental beneficial infection inform policy.