Beta 1 integrins in third trimester human placentae: No differential expression in pathological pregnancy

摘要: Abstract Integrins are a group of cell surface receptors that play important roles in cell-cell and cell-extracellular matrix interactions. The expression trophoblast integrin subunits changes during placental development normal pregnancy but the functional significance is unknown. aim this study was to investigate β1 integrins their extracellular ligands human placenta membranes pathological using an avidin-biotin-peroxidase technique. Expression similar all groups. Whilst there some heterogeneity specific chains not characteristic defined subject groups, variations occurring within Two distinct subpopulations were demonstrated chorion laeve according differential integrins. Trophoblast immediately adjacent maternal decidua, which expressed al rather than α2, also comprised majority basal plate; possession α1, α3, α5, α6 phenotype may be invasive potential populations. results obtained present indicate phenotypes third trimester uteroplacental tissues pregnancy, including pre-eclampsia, before after labour.