Ca2+ signaling and Src-kinases-controlled cellular functions.

摘要: Calcium-mediated signaling and the functionality of Src-family tyrosine kinases (SFKs) are two interconnected processes. Activation these kinases, which coupled to a series receptors, mediates Ca2+ mobilization by regulating channels, generated signal in turn exerts control on kinase activity via calmodulin. In this review, we shall cover regulation selected processes where crosstalk between SFKs occurs during lifespan cell, when subjected different extracellular or intracellular stimuli. These events result modulation many physiological processes, essential maintain organismal homeostasis. We discuss importance mechanisms, implicated pathways cellular comprising proliferation, differentiation, cell adhesion, migration, cytoskeletal remodeling, oocyte fertilization, apoptosis autophagy. Thereafter, role that exert functions, including hormones/neurotransmitters release, striated smooth muscle contraction, glomerular filtration, stress response, response viral bacterial infections.