Optical Coherence Tomography Reflective Drusen Substructures Predict Progression to Geographic Atrophy in Age-related Macular Degeneration.

摘要: Purpose Structural and compositional heterogeneity within drusen comprising lipids, carbohydrates, proteins have been previously described. We sought to detect define phenotypic patterns of in the form optical coherence tomography–reflective substructures (ODS) examine their associations with age-related macular degeneration (AMD)–related features AMD progression. Design Retrospective analysis a prospective study. Participants Patients intermediate (n = 349) enrolled multicenter Age-Related Eye Disease Study 2 (AREDS2) ancillary spectral-domain tomography (SD OCT) Methods Baseline SD OCT scans 1 eye per patient were analyzed for presence ODS. Cross-sectional longitudinal ODS AMD-related visible on color photographs, including volume, geographic atrophy (GA), preatrophic features, evaluated entire region. Similar also made locally 0.5-mm-diameter region around individual corresponding control without same eye. Main Outcome Measures Preatrophy changes GA, central choroidal neovascularization (CNV) from photographs. Results Four subtypes defined: low reflective cores, high conical debris, split drusen. Among 349 participants, there 307 eligible eyes 74 (24%) had at least The baseline associated (1) greater volume ( P  = 0.001–0.01), (3) development GA 0.005) year 3 0.002–0.008), but not CNV. local preatrophy 0.02–0.03) (2) years 0.008–0.05). Conclusions Optical are tomography–based biomarkers progression CNV, AMD. may be clinical entity helpful monitoring informing mechanisms pathogenesis.