Aberrant expression of X-linked genes RbAp46, Rsk4, and Cldn2 in breast cancer.
作者： Archana Thakur , KM Wahidur Rahman , Jack Wu , Aliccia Bollig , Hector Biliran
DOI: 10.1158/1541-7786.MCR-06-0071
关键词:
摘要: The consequence of activation status or gain/loss an X-chromosome in terms the expression tumor suppressor genes oncogenes breast cancer has not been clearly addressed. In this study, we investigated X-chromosomes a panel human cell lines, carcinoma, and adjacent mammary tissues murine epithelial sublines ranging from low to high invasive potentials. Results show that most lines were homozygous, but both benign heterozygous for highly polymorphic X-loci (IDS G6PD). On other hand, 60% carcinoma cases either IDS G6PD markers. Investigation revealed presence only one active X-chromosome, whereas had two X-chromosomes. Furthermore, determined whether additional affects levels oncogenes. Reverse transcription-PCR data putative Rsk4 RbAp46 47% 79% cases, respectively, Cldn2 was down-regulated 52% compared with normal tissues. Consistent mRNA expression, immunostaining these proteins also showed similar pattern. conclusion, our suggest is likely have role development progression cancer. may influence X-linked genes.
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